Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes

Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes

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Summary: High-protein diets are promoted for individuals with type 2 tillman 750m diabetes (T2D).However, effects of dietary protein interventions on (gut-derived) metabolites in T2D remains understudied.We therefore performed a multi-center, randomized-controlled, isocaloric protein intervention with 151 participants following either 12-week high-protein (HP; 30Energy %, N = 78) vs.

low-protein (LP; 10 Energy%, N = 73) diet.Primary objectives were dietary effects on glycemic control which were determined via glycemic excursions, continuous glucose monitors and HbA1c.Secondary objectives were impact of diet on gut microbiota composition and -derived metabolites which were determined by shotgun-metagenomics and mass spectrometry.

Analyses were performed using delta changes itsmajorlook.com adjusting for center, baseline, and kidney function when appropriate.This study found that a short-term 12-week isocaloric protein modulation does not affect glycemic parameters or weight in metformin-treated T2D.However, the HP diet slightly worsened kidney function, increased alpha-diversity, and production of potentially harmful microbiota-dependent metabolites, which may affect host metabolism upon prolonged exposure.